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| Research > Clinical Epidemiology > Neurobiology > Respiratory Failure > Cardio-Metabolic and Endocrine > Circadian and Sleep Biology > Medical Psychology> Upper Airway Structure and Function | Quick Links |
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RESEARCHRespiratory FailureSleep is associated with a number of effects on respiration, including changes in central respiratory control, airways resistance, and muscular contractility. There is strong evidence to suggest that some these physiological changes may have adverse effects on respiration and gas exchange in patients with certain underlying diseases and conditions. This can lead to an increased risk of daytime hypoxaemia and hypercapnia in OSA patients with co-existing lung disease, usually chronic obstructive pulmonary disease. The purpose of the Respiratory Failure Group is to investigate the mechanisms by which sleep influences respiratory failure, and to develop improved strategies to manage sleep-related deterioration in gas exchange in affected individuals. The group is currently comparing the use of CPAP and bilevel therapy for patients suffering from obesity-hypoventilation syndrome. The group has also recently completed a study looking at altering inspiratory duration and chinstrap use during bilevel therapy. The results of this randomised trial will allow clinicians to evaluate the likely impact of controlling inspiratory duration, with and without the use of a chinstrap, on nocturnal gas exchange and sleep quality. Another study is investigating the effects of using non-invasive ventilation (NIV) during exercise in patients with respiratory failure or respiratory insufficiency. Dr Amanda Piper
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