LINKS |
| Research > Clinical Epidemiology > Neurobiology > Respiratory Failure > Cardio-Metabolic and Endocrine > Circadian and Sleep Biology > Medical Psychology > Upper Airway Structure and Function | Quick Links |
|||
|
|
||||
RESEARCHNeurobiologyMany neurobiological and neurobehavioural/neurocognitive activities are influenced by the sleep-wake and circadian systems. The Neurobiology Group is interested in investigating the effects of sleep loss and sleep disruption on the brain and human performance. The group is currently investigating the effect of CPAP withdrawal on n eurocognitive performance, physiological variables and sleep, in OSA patients. This research is relevant to patients who are unable to use their CPAP machines for periods of time, such as when they travel or have a respiratory infection. Further studies over the coming year will look at the effects of medications in ameliorating the effects of short-term withdrawal from CPAP therapy. To better understand the brain mechanisms underlying these changes, we are also investigating the alterations in brain activity that occur as a result of OSA, and again following commencement of treatment with CPAP Another aspect of our research relates to investigating sleepiness, driving simulator performance and electroencephalography during sleep deprivation. With increased hours of wakefulness, sleepiness increases and performance on a driving simulator deteriorates. The presence of medical disorders such as sleep apnea might further add to this sleepiness. We are studying healthy volunteers and people with OSA to examine the effect of sleep deprivation on reaction time and driving simulator performance. Further studies will assess the suitability of the electroencephalogram as a measure of sleepiness. Professor Ron Grunstein
|
© 2007